Roberto Testi Selected Research

Mitochondrial Proteins (Mitochondrial Protein)

1/2022	Drug Repositioning in Friedreich Ataxia.
1/2018	Biophysical characterisation of the recombinant human frataxin precursor.
1/2017	E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia.
1/2015	Analyzing the Effects of a G137V Mutation in the FXN Gene.
2/2013	Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans.
8/2010	A role for p53 in mitochondrial stress response control of longevity in C. elegans.
4/2010	Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin.
8/2009	p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress.
4/2005	Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans.

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Roberto Testi Research Topics

Disease

22	Friedreich Ataxia (Friedreich's Ataxia) 01/2022 - 04/2005
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 07/2007
4	Mitochondrial Diseases (Mitochondrial Disease) 01/2019 - 10/2006
3	Ataxia (Dyssynergia) 08/2015 - 04/2005
2	COVID-19 01/2021 - 08/2020
2	Cardiomyopathies (Cardiomyopathy) 04/2010 - 06/2006
2	Neoplasms (Cancer) 01/2008 - 05/2006
1	Heart Failure 01/2022
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2022
1	Rare Diseases (Rare Disease) 01/2022
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2022
1	Celiac Disease (Celiac Sprue) 10/2020
1	Crohn Disease (Crohn's Disease) 10/2020
1	Diarrhea 10/2020
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 10/2020
1	Vascular Diseases (Vascular Disease) 08/2020
1	Infections 08/2020
1	Heart Diseases (Heart Disease) 01/2020
1	Cerebellar Ataxia (Dysmetria) 01/2019
1	Sporadic Creutzfeldt-Jakob Disease 01/2019
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2019
1	Scrapie 01/2019
1	Disease Progression 03/2015
1	Hodgkin Disease (Hodgkin's Disease) 01/2008
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2008
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2008
1	Lymphoma (Lymphomas) 01/2008
1	Colitis 10/2006
1	Colorectal Neoplasms (Colorectal Cancer) 10/2006
1	Ischemia 03/2004
1	Hypoxia (Hypoxemia) 03/2004
1	Glioblastoma (Glioblastoma Multiforme) 12/2002

Drug/Important Bio-Agent (IBA)

20	FrataxinIBA 01/2022 - 04/2005
9	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2022 - 04/2005
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2008
4	Pharmaceutical PreparationsIBA 01/2022 - 10/2006
2	Biomarkers (Surrogate Marker)IBA 08/2020 - 01/2020
2	Interferon-gamma (Interferon, gamma)IBA 01/2020 - 07/2012
2	Aconitate Hydratase (Aconitase)IBA 01/2019 - 03/2015
2	IronIBA 01/2019 - 01/2015
2	UbiquitinIBA 03/2015 - 04/2011
2	Phosphotransferases (Kinase)IBA 01/2008 - 05/2006
1	RacivirIBA 10/2020
1	Emtricitabine (Emtriva)FDA Link 10/2020
1	Tenofovir (Viread)FDA Link 10/2020
1	Factor VIII (Coagulation Factor VIII)IBA 08/2020
1	InterferonsIBA 01/2020
1	Retinaldehyde (Retinal)IBA 01/2020
1	etravirine (TMC-125)FDA Link 01/2019
1	EnzymesIBA 01/2019
1	Prion ProteinsIBA 01/2019
1	Messenger RNA (mRNA)IBA 01/2019
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2017
1	SulfurIBA 01/2015
1	Proteasome Endopeptidase Complex (Proteasome)IBA 04/2011
1	AntioxidantsIBA 08/2010
1	Glutathione Transferase (Glutathione S-Transferase)IBA 08/2010
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2008
1	DNA (Deoxyribonucleic Acid)IBA 10/2006
1	Mitochondrial DNA (mtDNA)IBA 10/2006
1	Mesalamine (Mesalazine)FDA LinkGeneric 10/2006
1	Tyrosine (L-Tyrosine)FDA Link 05/2006
1	CaspasesIBA 05/2006
1	Nitric Oxide DonorsIBA 03/2004
1	cobaltous chloride (cobalt(II)chloride)IBA 03/2004
1	Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric 03/2004
1	EsterasesIBA 12/2002

Therapy/Procedure

3	Therapeutics 01/2022 - 03/2016
1	Gastrectomy 10/2020
1	Ligation 03/2004